In vitro nanobody discovery for integral membrane protein targets

Nanobodies (Nbs) or single-domain antibodies are among the smallest and most stable binder scaffolds known. In vitro display is a powerful antibody discovery technique used worldwide. We describe the first adaptation of in vitro mRNA/cDNA display for the rapid, automatable discovery of Nbs against d...

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Detalles Bibliográficos
Autores principales: Doshi, Rupak, Chen, Beverly R., Vibat, Cecile Rose T., Huang, Norman, Lee, Chang-Wook, Chang, Geoffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208029/
https://www.ncbi.nlm.nih.gov/pubmed/25342225
http://dx.doi.org/10.1038/srep06760

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208029/
https://www.ncbi.nlm.nih.gov/pubmed/25342225
http://dx.doi.org/10.1038/srep06760

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