Differential effects of glyoxalase 1 overexpression on diabetic atherosclerosis and renal dysfunction in streptozotocin‐treated, apolipoprotein E‐deficient mice

The reactive dicarbonyls, glyoxal and methylglyoxal (MG), increase in diabetes and may participate in the development of diabetic complications. Glyoxal and MG are detoxified by the sequential activities of glyoxalase 1 (GLO1) and glyoxalase 2. To determine the contribution of these dicarbonyls to t...

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Detalles Bibliográficos
Autores principales: Geoffrion, Michèle, Du, Xueliang, Irshad, Zehra, Vanderhyden, Barbara C., Courville, Kerri, Sui, Guangzhi, D'Agati, Vivette D., Ott‐Braschi, Sylvie, Rabbani, Naila, Thornalley, Paul J., Brownlee, Michael, Milne, Ross W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Periodicals, Inc. 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208644/
https://www.ncbi.nlm.nih.gov/pubmed/24920125
http://dx.doi.org/10.14814/phy2.12043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208644/
https://www.ncbi.nlm.nih.gov/pubmed/24920125
http://dx.doi.org/10.14814/phy2.12043

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