BCR-ABL Promotes PTEN Downregulation in Chronic Myeloid Leukemia

Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by the t(9;22) translocation coding for the chimeric protein p210 BCR-ABL. The tumor suppressor PTEN plays a critical role in the pathogenesis of CML chronic phase, through non genomic loss of function mechanisms, such as...

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Detalles Bibliográficos
Autores principales: Panuzzo, Cristina, Crivellaro, Sabrina, Carrà, Giovanna, Guerrasio, Angelo, Saglio, Giuseppe, Morotti, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208795/
https://www.ncbi.nlm.nih.gov/pubmed/25343485
http://dx.doi.org/10.1371/journal.pone.0110682

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208795/
https://www.ncbi.nlm.nih.gov/pubmed/25343485
http://dx.doi.org/10.1371/journal.pone.0110682

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