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Effect of Antigen Shedding on Targeted Delivery of Immunotoxins in Solid Tumors from a Mathematical Model

Most cancer-specific antigens used as targets of antibody-drug conjugates and immunotoxins are shed from the cell surface (Zhang & Pastan (2008) Clin. Cancer Res. 14: 7981-7986), although at widely varying rates and by different mechanisms (Dello Sbarba & Rovida (2002) Biol. Chem. 383: 69–83...

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Detalles Bibliográficos
Autores principales: Pak, Youngshang, Pastan, Ira, Kreitman, Robert J., Lee, Byungkook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208831/
https://www.ncbi.nlm.nih.gov/pubmed/25343405
http://dx.doi.org/10.1371/journal.pone.0110716