Dual Effects of Ketoconazole cis-Enantiomers on CYP3A4 in Human Hepatocytes and HepG2 Cells

Antifungal drug ketoconazole causes severe drug-drug interactions by influencing gene expression and catalytic activity of major drug-metabolizing enzyme cytochrome P450 CYP3A4. Ketoconazole is administered in the form of racemic mixture of two cis-enantiomers, i.e. (+)-ketoconazole and (−)-ketocona...

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Detalles Bibliográficos
Autores principales: Novotná, Aneta, Krasulová, Kristýna, Bartoňková, Iveta, Korhoňová, Martina, Bachleda, Petr, Anzenbacher, Pavel, Dvořák, Zdeněk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208844/
https://www.ncbi.nlm.nih.gov/pubmed/25343516
http://dx.doi.org/10.1371/journal.pone.0111286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208844/
https://www.ncbi.nlm.nih.gov/pubmed/25343516
http://dx.doi.org/10.1371/journal.pone.0111286

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