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Potential new therapeutic modality revealed through agent-based modeling of the neuromuscular junction and acetylcholinesterase inhibition

BACKGROUND: One of the leading causes of death and illness within the agriculture industry is through unintentionally ingesting or inhaling organophosphate pesticides. OP intoxication directly inhibits acetylcholinesterase, resulting in an excitatory signaling cascade leading to fasciculation, loss...

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Detalles Bibliográficos
Autores principales: Chapleau, Richard R, Robinson, Peter J, Schlager, John J, Gearhart, Jeffery M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209019/
https://www.ncbi.nlm.nih.gov/pubmed/25273339
http://dx.doi.org/10.1186/1742-4682-11-42