Cargando…

Potential new therapeutic modality revealed through agent-based modeling of the neuromuscular junction and acetylcholinesterase inhibition

BACKGROUND: One of the leading causes of death and illness within the agriculture industry is through unintentionally ingesting or inhaling organophosphate pesticides. OP intoxication directly inhibits acetylcholinesterase, resulting in an excitatory signaling cascade leading to fasciculation, loss...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chapleau, Richard R, Robinson, Peter J, Schlager, John J, Gearhart, Jeffery M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209019/ https://www.ncbi.nlm.nih.gov/pubmed/25273339 http://dx.doi.org/10.1186/1742-4682-11-42

Ejemplares similares

THE LOCALIZATION OF ACETYLCHOLINESTERASE AT THE AUTONOMIC NEUROMUSCULAR JUNCTION
por: Robinson, Peter M., et al.
Publicado: (1967)

Acetylcholinesterase Clustering at the Neuromuscular Junction Involves Perlecan and Dystroglycan
por: Peng, H. Benjamin, et al.
Publicado: (1999)

MuSK is required for anchoring acetylcholinesterase at the neuromuscular junction
por: Cartaud, Annie, et al.
Publicado: (2004)

Fine Localization of Acetylcholinesterase in the Synaptic Cleft of the Vertebrate Neuromuscular Junction
por: Blotnick-Rubin, Edna, et al.
Publicado: (2018)

Donepezil inhibits neuromuscular junctional acetylcholinesterase and enhances synaptic transmission and function in isolated skeletal muscle
por: Redman, Robert R., et al.
Publicado: (2022)

Neuromuscular Junction Impairment in Amyotrophic Lateral Sclerosis: Reassessing the Role of Acetylcholinesterase
por: Campanari, Maria-Letizia, et al.
Publicado: (2016)

The Effects of Exercise-induced Fatigue on Acetylcholinesterase Expression and Activity at Rat Neuromuscular Junctions
por: Wen, Guo, et al.
Publicado: (2009)

The Role of Oxidative Stress in Decreased Acetylcholinesterase Activity at the Neuromuscular Junction of the Diaphragm during Sepsis
por: Liu, Hua, et al.
Publicado: (2017)

Physiologically based pharmacokinetic model for the inhibition of acetylcholinesterase by organophosphate esters.
por: Gearhart, J M, et al.
Publicado: (1994)

Axons Compete for Neuromuscular Junctions
por: Robinson, Richard
Publicado: (2012)

ELECTRON MICROSCOPIC LOCALIZATION OF ACETYLCHOLINESTERASE AND NONSPECIFIC CHOLINESTERASE AT THE NEUROMUSCULAR JUNCTION BY THE GOLD-THIOCHOLINE AND GOLD-THIOLACETIC ACID METHODS
por: Davis, Richard, et al.
Publicado: (1967)

Autoregulation of Acetylcholine Release and Micro-Pharmacodynamic Mechanisms at Neuromuscular Junction: Selective Acetylcholinesterase Inhibitors for Therapy of Myasthenic Syndromes
por: Petrov, Konstantin A., et al.
Publicado: (2018)

THE FINE STRUCTURAL LOCALIZATION OF ACETYLCHOLINESTERASE AT THE MYONEURAL JUNCTION
por: Barrnett, Russell J.
Publicado: (1962)

Neural regulation of acetylcholinesterase mRNAs at mammalian neuromuscular synapses
Publicado: (1994)

The Distribution of Pre- and Postsynaptic Inhibition at Crustacean Neuromuscular Junctions
por: Kennedy, Donald, et al.
Publicado: (1966)

The Neuromuscular Junction: Roles in Aging and Neuromuscular Disease
por: Iyer, Shama R., et al.
Publicado: (2021)

Reconstruction of the neuromuscular junction connectome
por: Srinivasan, Ranga, et al.
Publicado: (2010)

Autoimmune Channelopathies at Neuromuscular Junction
por: Huang, Kun, et al.
Publicado: (2019)

Neuromuscular Junctions as Key Contributors and Therapeutic Targets in Spinal Muscular Atrophy
por: Boido, Marina, et al.
Publicado: (2016)

Transplantation of Quail Collagen-tailed Acetylcholinesterase Molecules Onto the Frog Neuromuscular Synapse
por: Rotundo, Richard L., et al.
Publicado: (1997)

Neuromuscular junctions are stable in patients with cancer cachexia
por: Boehm, Ines, et al.
Publicado: (2020)

Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer’s Disease
por: Toublet, François-Xavier, et al.
Publicado: (2019)

Targeting Therapy to The Neuromuscular Junction: Proof of Concept
por: Kusner, Linda L, et al.
Publicado: (2014)

N-CAM at the vertebrate neuromuscular junction
Publicado: (1985)

Desensitization and recovery at the frog neuromuscular junction
Publicado: (1977)

Molecular control of neuromuscular junction development
por: Ferraro, Elisabetta, et al.
Publicado: (2011)

Neuregulins show their support for neuromuscular junctions
por: Leslie, Mitch
Publicado: (2011)

Neurexin in Embryonic Drosophila Neuromuscular Junctions
por: Chen, Kaiyun, et al.
Publicado: (2010)

Degeneration of Neuromuscular Junction in Age and Dystrophy
por: Rudolf, Rüdiger, et al.
Publicado: (2014)

Electrophysiological study in neuromuscular junction disorders
por: Cherian, Ajith, et al.
Publicado: (2013)

Endomicroscopy and electromyography of neuromuscular junctions in situ
por: Brown, Rosalind, et al.
Publicado: (2014)

Rejuvenation of the aged neuromuscular junction by exercise
por: Kreko-Pierce, Tabita, et al.
Publicado: (2018)

Comparative anatomy of the mammalian neuromuscular junction
por: Boehm, Ines, et al.
Publicado: (2020)

Protein–lipid interplay at the neuromuscular junction
por: Unwin, Nigel
Publicado: (2022)

Adaptive Remodeling of the Neuromuscular Junction with Aging
por: Deschenes, Michael R., et al.
Publicado: (2022)

Effects of Natural Products on Neuromuscular Junction
por: Akkol, Esra Küpeli, et al.
Publicado: (2022)

Myotubular myopathy and the neuromuscular junction: a novel therapeutic approach from mouse models
por: Dowling, James J., et al.
Publicado: (2012)

Caffeine Inhibits Acetylcholinesterase, But Not Butyrylcholinesterase
por: Pohanka, Miroslav, et al.
Publicado: (2013)

Terminal Schwann cells at the human neuromuscular junction
por: Alhindi, Abrar, et al.
Publicado: (2021)

Cellular and Molecular Anatomy of the Human Neuromuscular Junction
por: Jones, Ross A., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_rqhfmcd8607duvhdgahtltfe44