Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer’s disease

The accumulation of neurofibrillary tangles in Alzheimer’s disease (AD) propagates with characteristic spatiotemporal patterns which follow brain network connections, implying trans-synaptic transmission of tauopathy. Since misfolded tau has been shown to transmit across synapses in AD animal models...

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Detalles Bibliográficos
Autores principales: Tai, Hwan-Ching, Wang, Bo Y, Serrano-Pozo, Alberto, Frosch, Matthew P, Spires-Jones, Tara L, Hyman, Bradley T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209049/
https://www.ncbi.nlm.nih.gov/pubmed/25330988
http://dx.doi.org/10.1186/s40478-014-0146-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209049/
https://www.ncbi.nlm.nih.gov/pubmed/25330988
http://dx.doi.org/10.1186/s40478-014-0146-2

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