Cargando…

Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer’s disease

The accumulation of neurofibrillary tangles in Alzheimer’s disease (AD) propagates with characteristic spatiotemporal patterns which follow brain network connections, implying trans-synaptic transmission of tauopathy. Since misfolded tau has been shown to transmit across synapses in AD animal models...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tai, Hwan-Ching, Wang, Bo Y, Serrano-Pozo, Alberto, Frosch, Matthew P, Spires-Jones, Tara L, Hyman, Bradley T
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209049/ https://www.ncbi.nlm.nih.gov/pubmed/25330988 http://dx.doi.org/10.1186/s40478-014-0146-2

Ejemplares similares

The Role of Protein Misfolding and Tau Oligomers (TauOs) in Alzheimer’s Disease (AD)
por: Mroczko, Barbara, et al.
Publicado: (2019)

Different tau species lead to heterogeneous tau pathology propagation and misfolding
por: Dujardin, Simon, et al.
Publicado: (2018)

Presynaptic Translation: Stepping Out of the Postsynaptic Shadow
por: Akins, Michael R., et al.
Publicado: (2009)

Symmetrical arrangement of proteins under release-ready vesicles in presynaptic terminals
por: Radhakrishnan, Abhijith, et al.
Publicado: (2021)

Comparing 3D ultrastructure of presynaptic and postsynaptic mitochondria
por: Delgado, Thomas, et al.
Publicado: (2019)

Tau association with synaptic vesicles causes presynaptic dysfunction
por: Zhou, Lujia, et al.
Publicado: (2017)

Characterization of Pairs of Toxic and Nontoxic Misfolded Protein Oligomers Elucidates the Structural Determinants of Oligomer Toxicity in Protein Misfolding Diseases
por: Limbocker, Ryan, et al.
Publicado: (2023)

Chaperones as Suppressors of Protein Misfolded Oligomer Toxicity
por: Mannini, Benedetta, et al.
Publicado: (2017)

Membrane Interactions and Toxicity by Misfolded Protein Oligomers
por: Gonzalez-Garcia, Mario, et al.
Publicado: (2021)

Metal Toxicity at the Synapse: Presynaptic, Postsynaptic, and Long-Term Effects
por: Sadiq, Sanah, et al.
Publicado: (2012)

Predicting Presynaptic and Postsynaptic Neurotoxins by Developing Feature Selection Technique
por: Tang, Hua, et al.
Publicado: (2017)

Cholesterol modulates presynaptic and postsynaptic properties of excitatory synaptic transmission
por: Korinek, Miloslav, et al.
Publicado: (2020)

Presynaptic contact and activity opposingly regulate postsynaptic dendrite outgrowth
por: Heckman, Emily L, et al.
Publicado: (2022)

Distinct responses of human peripheral blood cells to different misfolded protein oligomers
por: Leal‐Lasarte, Magdalena, et al.
Publicado: (2021)

The elusive nature and diagnostics of misfolded Aβ oligomers
por: Cerasoli, Eleonora, et al.
Publicado: (2015)

Therapeutic Strategies to Reduce the Toxicity of Misfolded Protein Oligomers
por: Kreiser, Ryan P., et al.
Publicado: (2020)

Differential control of presynaptic efficacy by postsynaptic N-cadherin and β-catenin
por: Vitureira, Nathalia, et al.
Publicado: (2011)

SNAP-25, a Known Presynaptic Protein with Emerging Postsynaptic Functions
por: Antonucci, Flavia, et al.
Publicado: (2016)

Prediction of presynaptic and postsynaptic neurotoxins by combining various Chou’s pseudo components
por: Huo, Haiyan, et al.
Publicado: (2017)

Postsynaptic Neuroligin-1 Mediates Presynaptic Endocytosis During Neuronal Activity
por: Luo, Jiaqi Keith, et al.
Publicado: (2021)

Selective Recruitment of Presynaptic and Postsynaptic Forms of mGluR-LTD
por: Sanderson, Thomas M., et al.
Publicado: (2022)

Reply: Soluble oligomers or insoluble fibrils?
por: Mate de Gerando, Anastasie, et al.
Publicado: (2023)

Tomosyn Expression Pattern in the Mouse Hippocampus Suggests Both Presynaptic and Postsynaptic Functions
por: Barak, Boaz, et al.
Publicado: (2010)

Diversification of behavior and postsynaptic properties by netrin-G presynaptic adhesion family proteins
por: Zhang, Qi, et al.
Publicado: (2016)

Nicotine regulates activity of lateral habenula neurons via presynaptic and postsynaptic mechanisms
por: Zuo, Wanhong, et al.
Publicado: (2016)

Postsynaptic, not presynaptic NMDA receptors are required for spike timing dependent LTD induction
por: Carter, Brett C., et al.
Publicado: (2016)

PELDOR in rotationally symmetric homo-oligomers
por: Giannoulis, Angeliki, et al.
Publicado: (2013)

Simultaneous two-photon activation of presynaptic cells and calcium imaging in postsynaptic dendritic spines
por: Matsuzaki, Masanori, et al.
Publicado: (2011)

Postsynaptic protein synthesis is required for presynaptic enhancement in persistent forms of long-term potentiation
por: Johnstone, Victoria P. A., et al.
Publicado: (2013)

Distinct homeostatic modulations stabilize reduced postsynaptic receptivity in response to presynaptic DLK signaling
por: Goel, Pragya, et al.
Publicado: (2018)

A familial Danish dementia rat shows impaired presynaptic and postsynaptic glutamatergic transmission
por: Yin, Tao, et al.
Publicado: (2021)

Characteristics of Tau Oligomers
por: Ren, Yan, et al.
Publicado: (2013)

Tau Oligomers Neurotoxicity
por: Niewiadomska, Grazyna, et al.
Publicado: (2021)

Postsynaptic Receptors for Amyloid-β Oligomers as Mediators of Neuronal Damage in Alzheimer’s Disease
por: Dinamarca, Margarita C., et al.
Publicado: (2012)

Coincident postsynaptic activity gates presynaptic dopamine release to induce plasticity in Drosophila mushroom bodies
por: Ueno, Kohei, et al.
Publicado: (2017)

Reelin Exerts Structural, Biochemical and Transcriptional Regulation Over Presynaptic and Postsynaptic Elements in the Adult Hippocampus
por: Bosch, Carles, et al.
Publicado: (2016)

Presynaptic MAST kinase controls opposing postsynaptic responses to convey stimulus valence in Caenorhabditis elegans
por: Nakano, Shunji, et al.
Publicado: (2020)

Kinesin-3 mediated axonal delivery of presynaptic neurexin stabilizes dendritic spines and postsynaptic components
por: Oliver, Devyn, et al.
Publicado: (2022)

Teneurins assemble into presynaptic nanoclusters that promote synapse formation via postsynaptic non-teneurin ligands
por: Zhang, Xuchen, et al.
Publicado: (2022)

Multiplexed Digital Characterization of Misfolded Protein Oligomers via Solid-State Nanopores
por: Sandler, Sarah E., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_mh5l5ss29b4b711ehnhm5hi78r