A human CCT5 gene mutation causing distal neuropathy impairs hexadecamer assembly in an archaeal model

Chaperonins mediate protein folding in a cavity formed by multisubunit rings. The human CCT has eight non-identical subunits and the His147Arg mutation in one subunit, CCT5, causes neuropathy. Knowledge is scarce on the impact of this and other mutations upon the chaperone's structure and funct...

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Detalles Bibliográficos
Autores principales: Min, Wonki, Angileri, Francesca, Luo, Haibin, Lauria, Antonino, Shanmugasundaram, Maruda, Almerico, Anna Maria, Cappello, Francesco, de Macario, Everly Conway, Lednev, Igor K., Macario, Alberto J. L., Robb, Frank T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209464/
https://www.ncbi.nlm.nih.gov/pubmed/25345891
http://dx.doi.org/10.1038/srep06688

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209464/
https://www.ncbi.nlm.nih.gov/pubmed/25345891
http://dx.doi.org/10.1038/srep06688

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