Immunoglobulin Free Light Chains and GAGs Mediate Multiple Myeloma Extracellular Vesicles Uptake and Secondary NfκB Nuclear Translocation

Multiple myeloma (MM) is a hematological malignancy caused by a microenviromentally aided persistence of plasma cells in the bone marrow. Monoclonal plasma cells often secrete high amounts of immunoglobulin free light chains (FLCs) that could induce tissue damage. Recently, we showed that FLCs are i...

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Detalles Bibliográficos
Autores principales: Di Noto, Giuseppe, Chiarini, Marco, Paolini, Lucia, Mazzoldi, Elena Laura, Giustini, Viviana, Radeghieri, Annalisa, Caimi, Luigi, Ricotta, Doris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209816/
https://www.ncbi.nlm.nih.gov/pubmed/25386176
http://dx.doi.org/10.3389/fimmu.2014.00517

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209816/
https://www.ncbi.nlm.nih.gov/pubmed/25386176
http://dx.doi.org/10.3389/fimmu.2014.00517

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