The behavioural response of mice lacking NK(1) receptors to guanfacine resembles its clinical profile in treatment of ADHD

BACKGROUND AND PURPOSE: Mice with functional ablation of substance P-preferring neurokinin-1 receptors (NK1R−/− mice) display behavioural abnormalities resembling those in attention deficit hyperactivity disorder (ADHD). Here, we investigated whether the ADHD treatment, guanfacine, alleviated the hy...

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Detalles Bibliográficos
Autores principales: Pillidge, Katharine, Porter, Ashley J, Dudley, Julia A, Tsai, Yuan-Chen, Heal, David J, Stanford, S Clare
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Themed Section: Animal Models in Psychiatry Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209942/
https://www.ncbi.nlm.nih.gov/pubmed/25074741
http://dx.doi.org/10.1111/bph.12860

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209942/
https://www.ncbi.nlm.nih.gov/pubmed/25074741
http://dx.doi.org/10.1111/bph.12860

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