Aerosol Azacytidine Inhibits Orthotopic Lung Cancers in Mice through Its DNA Demethylation and Gene Reactivation Effects

We devised an aerosol based demethylation therapy to achieve therapeutic efficacy in premalignant or in situ lesions of lung cancer, without systemic toxicity. Optimum regimens of aerosolized azacytidine (Aza) were designed and used in orthotopic human non-small cell lung cancer xenograft models. Th...

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Detalles Bibliográficos
Autores principales: Qiu, Xuan, Liang, Yuanxin, Sellers, Rani S., Perez-Soler, Roman, Zou, Yiyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210052/
https://www.ncbi.nlm.nih.gov/pubmed/25347303
http://dx.doi.org/10.1371/journal.pone.0109874

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210052/
https://www.ncbi.nlm.nih.gov/pubmed/25347303
http://dx.doi.org/10.1371/journal.pone.0109874

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