A General and Enantioselective Approach to Pentoses: A Rapid Synthesis of PSI-6130, the Nucleoside Core of Sofosbuvir

[Image: see text] An efficient route towards biologically relevant pentose derivatives is described. The de novo synthetic strategy features an enantioselective α-oxidation reaction enabled by a chiral amine in conjunction with copper(II) catalysis. A subsequent Mukaiyama aldol coupling allows for t...

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Detalles Bibliográficos
Autores principales: Peifer, Manuel, Berger, Raphaëlle, Shurtleff, Valerie W., Conrad, Jay C., MacMillan, David W. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210058/
https://www.ncbi.nlm.nih.gov/pubmed/24670208
http://dx.doi.org/10.1021/ja502205q

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210058/
https://www.ncbi.nlm.nih.gov/pubmed/24670208
http://dx.doi.org/10.1021/ja502205q

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