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Computational Study of Gleevec and G6G Reveals Molecular Determinants of Kinase Inhibitor Selectivity
[Image: see text] Gleevec is a potent inhibitor of Abl tyrosine kinase but not of the highly homologous c-Src kinase. Because the ligand binds to an inactive form of the protein in which an Asp-Phe-Gly structural motif along the activation loop adopts a so-called DFG-out conformation, it was suggest...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210138/ https://www.ncbi.nlm.nih.gov/pubmed/25243930 http://dx.doi.org/10.1021/ja504146x |