Altered Ca(2+) signaling in skeletal muscle fibers of the R6/2 mouse, a model of Huntington’s disease

Huntington’s disease (HD) is caused by an expanded CAG trinucleotide repeat within the gene encoding the protein huntingtin. The resulting elongated glutamine (poly-Q) sequence of mutant huntingtin (mhtt) affects both central neurons and skeletal muscle. Recent reports suggest that ryanodine recepto...

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Detalles Bibliográficos
Autores principales: Braubach, Peter, Orynbayev, Murat, Andronache, Zoita, Hering, Tanja, Landwehrmeyer, Georg Bernhard, Lindenberg, Katrin S., Melzer, Werner
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210430/
https://www.ncbi.nlm.nih.gov/pubmed/25348412
http://dx.doi.org/10.1085/jgp.201411255

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210430/
https://www.ncbi.nlm.nih.gov/pubmed/25348412
http://dx.doi.org/10.1085/jgp.201411255

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