Cargando…

Altered Ca(2+) signaling in skeletal muscle fibers of the R6/2 mouse, a model of Huntington’s disease

Huntington’s disease (HD) is caused by an expanded CAG trinucleotide repeat within the gene encoding the protein huntingtin. The resulting elongated glutamine (poly-Q) sequence of mutant huntingtin (mhtt) affects both central neurons and skeletal muscle. Recent reports suggest that ryanodine recepto...

Descripción completa

Detalles Bibliográficos
Autores principales:	Braubach, Peter, Orynbayev, Murat, Andronache, Zoita, Hering, Tanja, Landwehrmeyer, Georg Bernhard, Lindenberg, Katrin S., Melzer, Werner
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2014
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210430/ https://www.ncbi.nlm.nih.gov/pubmed/25348412 http://dx.doi.org/10.1085/jgp.201411255

Ejemplares similares

Fast-to-Slow Transition of Skeletal Muscle Contractile Function and Corresponding Changes in Myosin Heavy and Light Chain Formation in the R6/2 Mouse Model of Huntington’s Disease
por: Hering, Tanja, et al.
Publicado: (2016)

Muscle weakness in Ryr1(I4895T/WT) knock-in mice as a result of reduced ryanodine receptor Ca(2+) ion permeation and release from the sarcoplasmic reticulum
por: Loy, Ryan E., et al.
Publicado: (2011)

Krankheitsmodifizierende Therapieansätze bei der Huntington-Krankheit: Blicke zurück und Blicke voraus
por: Frank, Wiebke, et al.
Publicado: (2021)

Two-Point Magnitude MRI for Rapid Mapping of Brown Adipose Tissue and Its Application to the R6/2 Mouse Model of Huntington Disease
por: Lindenberg, Katrin S., et al.
Publicado: (2014)

Establishing normative data for the evaluation of cognitive performance in Huntington’s disease considering the impact of gender, age, language, and education
por: Mühlbäck, Alžbeta, et al.
Publicado: (2023)

Altered Inactivation of Ca(2+) Current and Ca(2+) Release in Mouse Muscle Fibers Deficient in the DHP receptor γ(1) subunit
por: Ursu, Daniel, et al.
Publicado: (2004)

Prodromal Huntington Disease as a Model for Functional Compensation of Early Neurodegeneration
por: Malejko, Kathrin, et al.
Publicado: (2014)

No voltage change at skeletal muscle SR membrane during Ca(2+) release—just Mermaids on acid
por: Melzer, Werner
Publicado: (2018)

Effect of Body Weight on Age at Onset in Huntington Disease: A Mendelian Randomization Study
por: van der Burg, Jorien M.M., et al.
Publicado: (2021)

Observing Huntington’s Disease: the European Huntington’s Disease Network’s REGISTRY
por: Orth, Michael, et al.
Publicado: (2011)

Skeletal muscle fibers: Inactivated or depleted after long depolarizations?
por: Melzer, Werner
Publicado: (2013)

Commentary: Acanthocytes identified in Huntington's disease
por: Peikert, Kevin, et al.
Publicado: (2022)

In vivo Ca(2+) dynamics induced by Ca(2+) injection in individual rat skeletal muscle fibers
por: Wakizaka, Mario, et al.
Publicado: (2017)

A mouse model of Huntington’s disease shows altered ultrastructure of transverse tubules in skeletal muscle fibers
por: Romer, Shannon H., et al.
Publicado: (2021)

The Ca(2+) influx through the mammalian skeletal muscle dihydropyridine receptor is irrelevant for muscle performance
por: Dayal, Anamika, et al.
Publicado: (2017)

Current Pharmacological Management in Juvenile Huntington’s Disease
por: Robertson, Lisa, et al.
Publicado: (2012)

Cerebrospinal fluid levels of proenkephalin and prodynorphin are differentially altered in Huntington’s and Parkinson’s disease
por: Barschke, Peggy, et al.
Publicado: (2022)

From α(1)s splicing to γ(1) function: A new twist in subunit modulation of the skeletal muscle L-type Ca(2+) channel
por: Melzer, Werner
Publicado: (2022)

Overlap between age-at-onset and disease-progression determinants in Huntington disease
por: Aziz, N. Ahmad, et al.
Publicado: (2018)

Huntington’s disease skeletal muscle has altered T-tubules
por: Khan, Muhammad S., et al.
Publicado: (2021)

Symptomatic treatment options for Huntington’s disease (guidelines of the German Neurological Society)
por: Saft, Carsten, et al.
Publicado: (2023)

Utilisation of Healthcare and Associated Services in Huntington’s disease: a data mining study
por: Busse, Monica, et al.
Publicado: (2011)

Localized nuclear and perinuclear Ca(2+) signals in intact mouse skeletal muscle fibers
por: Georgiev, Tihomir, et al.
Publicado: (2015)

Comprehensive Simulation of Ca(2+) Transients in the Continuum of Mouse Skeletal Muscle Fiber Types
por: Rincón, Oscar A., et al.
Publicado: (2021)

Skeletal muscle pathology in Huntington's disease
por: Zielonka, Daniel, et al.
Publicado: (2014)

Progressive alterations in white matter microstructure across the timecourse of Huntington's disease
por: Estevez‐Fraga, Carlos, et al.
Publicado: (2023)

The gene coding for PGC-1α modifies age at onset in Huntington's Disease
por: Weydt, Patrick, et al.
Publicado: (2009)

Intact sensory-motor network structure and function in far from onset premanifest Huntington’s disease
por: Gorges, Martin, et al.
Publicado: (2017)

Ca2+ dependence of transverse tubule-mediated calcium release in skinned skeletal muscle fibers
por: Volpe, P, et al.
Publicado: (1986)

Block of single L-type Ca2+ channels in skeletal muscle fibers by aminoglycoside antibiotics
Publicado: (1996)

Characterization of the effects of Mg2+ on Ca2+- and Sr2+-activated tension generation of skinned skeletal muscle fibers
Publicado: (1975)

The effects of Suramin on Ca(2+) activated force and sarcoplasmic reticulum Ca(2+) release in skinned fast‐twitch skeletal muscle fibers of the rat
por: Williams, Dane W., et al.
Publicado: (2017)

A single nucleotide polymorphism in the coding region of PGC-1α is a male-specific modifier of Huntington disease age-at-onset in a large European cohort
por: Weydt, Patrick, et al.
Publicado: (2014)

Nucleolar stress controls mutant Huntington toxicity and monitors Huntington’s disease progression
por: Sönmez, Aynur, et al.
Publicado: (2021)

Voltage-dependent Ca(2+) Fluxes in Skeletal Myotubes Determined Using a Removal Model Analysis
por: Schuhmeier, R.P., et al.
Publicado: (2004)

An International Validation of a Clinical Tool to Assess Carers’ Quality of Life in Huntington’s Disease
por: Aubeeluck, Aimee, et al.
Publicado: (2019)

Enroll-HD: An Integrated Clinical Research Platform and Worldwide Observational Study for Huntington's Disease
por: Sathe, Swati, et al.
Publicado: (2021)

SR Ca(2+) leak in skeletal muscle fibers acts as an intracellular signal to increase fatigue resistance
por: Ivarsson, Niklas, et al.
Publicado: (2019)

Priority Strategy of Intracellular Ca(2+) Homeostasis in Skeletal Muscle Fibers during the Multiple Stresses of Hibernation
por: Zhang, Jie, et al.
Publicado: (2019)

Senescence Is Associated With Elevated Intracellular Resting [Ca(2 +)] in Mice Skeletal Muscle Fibers. An in vivo Study
por: Mijares, Alfredo, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_e8n16vf1l6700k3olqj6p8tfcr