Sulfonylureas suppress the stimulatory action of Mg-nucleotides on Kir6.2/SUR1 but not Kir6.2/SUR2A K(ATP) channels: A mechanistic study

Sulfonylureas, which stimulate insulin secretion from pancreatic β-cells, are widely used to treat both type 2 diabetes and neonatal diabetes. These drugs mediate their effects by binding to the sulfonylurea receptor subunit (SUR) of the ATP-sensitive K(+) (K(ATP)) channel and inducing channel closu...

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Detalles Bibliográficos
Autores principales: Proks, Peter, de Wet, Heidi, Ashcroft, Frances M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210431/
https://www.ncbi.nlm.nih.gov/pubmed/25348414
http://dx.doi.org/10.1085/jgp.201411222

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210431/
https://www.ncbi.nlm.nih.gov/pubmed/25348414
http://dx.doi.org/10.1085/jgp.201411222

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