LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues

Somatic inactivation of the serine/threonine kinase gene STK11/LKB1/PAR-4 occurs in a variety of cancers, including ∼10% of melanoma. However, how the loss of LKB1 activity facilitates melanoma invasion and metastasis remains poorly understood. In LKB1-null cells derived from an autochthonous murine...

Descripción completa

Detalles Bibliográficos
Autores principales: Chan, Keefe T., Asokan, Sreeja B., King, Samantha J., Bo, Tao, Dubose, Evan S., Liu, Wenjin, Berginski, Matthew E., Simon, Jeremy M., Davis, Ian J., Gomez, Shawn M., Sharpless, Norman E., Bear, James E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210439/
https://www.ncbi.nlm.nih.gov/pubmed/25349262
http://dx.doi.org/10.1083/jcb.201404067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210439/
https://www.ncbi.nlm.nih.gov/pubmed/25349262
http://dx.doi.org/10.1083/jcb.201404067

Ejemplares similares