Inhibition of autophagy potentiates the efficacy of Gli inhibitor GANT-61 in MYCN-amplified neuroblastoma cells

BACKGROUND: Aberrant Hedgehog (Hh) signaling is often associated with neuroblastoma (NB), a childhood malignancy with varying clinical outcomes due to different molecular characteristics. Inhibition of Hh signaling with small molecule inhibitors, particularly with GANT-61, significantly suppresses N...

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Detalles Bibliográficos
Autores principales: Wang, Jing, Gu, Song, Huang, Jun, Chen, Sheng, Zhang, Zhen, Xu, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210511/
https://www.ncbi.nlm.nih.gov/pubmed/25323222
http://dx.doi.org/10.1186/1471-2407-14-768

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210511/
https://www.ncbi.nlm.nih.gov/pubmed/25323222
http://dx.doi.org/10.1186/1471-2407-14-768

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