Altered synaptic structure in the hippocampus in a mouse model of Alzheimer’s disease with soluble amyloid-β oligomers and no plaque pathology

BACKGROUND: Mounting evidence suggests that soluble oligomers of amyloid-β (oAβ) represent the pertinent synaptotoxic form of Aβ in sporadic Alzheimer’s disease (AD); however, the mechanistic links between oAβ and synaptic degeneration remain elusive. Most in vivo experiments to date have been limit...

Descripción completa

Detalles Bibliográficos
Autores principales: Price, Katherine A, Varghese, Merina, Sowa, Allison, Yuk, Frank, Brautigam, Hannah, Ehrlich, Michelle E, Dickstein, Dara L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210526/
https://www.ncbi.nlm.nih.gov/pubmed/25312309
http://dx.doi.org/10.1186/1750-1326-9-41

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210526/
https://www.ncbi.nlm.nih.gov/pubmed/25312309
http://dx.doi.org/10.1186/1750-1326-9-41

Ejemplares similares