Sulfated Glycosaminoglycans Control the Extracellular Trafficking and the Activity of the Metalloprotease Inhibitor TIMP-3

Tissue inhibitor of metalloproteinase 3 (TIMP-3) is an important regulator of extracellular matrix (ECM) turnover. TIMP-3 binds to sulfated ECM glycosaminoglycans or is endocytosed by cells via low-density lipoprotein receptor-related protein 1 (LRP-1). Here, we report that heparan sulfate (HS) and...

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Detalles Bibliográficos
Autores principales: Troeberg, Linda, Lazenbatt, Christopher, Anower-E-Khuda, Md. Ferdous, Freeman, Craig, Federov, Oleg, Habuchi, Hiroko, Habuchi, Osami, Kimata, Koji, Nagase, Hideaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210636/
https://www.ncbi.nlm.nih.gov/pubmed/25176127
http://dx.doi.org/10.1016/j.chembiol.2014.07.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210636/
https://www.ncbi.nlm.nih.gov/pubmed/25176127
http://dx.doi.org/10.1016/j.chembiol.2014.07.014

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