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Kinetic competition during the transcription cycle results in stochastic RNA processing

Synthesis of mRNA in eukaryotes involves the coordinated action of many enzymatic processes, including initiation, elongation, splicing, and cleavage. Kinetic competition between these processes has been proposed to determine RNA fate, yet such coupling has never been observed in vivo on single tran...

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Detalles Bibliográficos
Autores principales: Coulon, Antoine, Ferguson, Matthew L, de Turris, Valeria, Palangat, Murali, Chow, Carson C, Larson, Daniel R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210818/
https://www.ncbi.nlm.nih.gov/pubmed/25271374
http://dx.doi.org/10.7554/eLife.03939