Suvanine Sesterterpenes from a Tropical Sponge Coscinoderma sp. Inhibit Isocitrate Lyase in the Glyoxylate Cycle

The glyoxylate cycle is a sequence of anaplerotic reactions catalyzed by the key enzymes isocitrate lyase (ICL) and malate synthase (MLS). Mutants of Candida albicans lacking ICL are markedly less virulent in mice than the wild-type. Suvanine sesterterpenes (1−9) isolated from a tropical sponge Cosc...

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Detalles Bibliográficos
Autores principales: Lee, So-Hyoung, Won, Tae Hyung, Kim, Heegyu, Ahn, Chan-Hong, Shin, Jongheon, Oh, Ki-Bong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210890/
https://www.ncbi.nlm.nih.gov/pubmed/25310766
http://dx.doi.org/10.3390/md12105148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210890/
https://www.ncbi.nlm.nih.gov/pubmed/25310766
http://dx.doi.org/10.3390/md12105148

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