A Mechanistic, Multiscale Mathematical Model of Immunogenicity for Therapeutic Proteins: Part 2—Model Applications

A mechanistic, multiscale mathematical model of immunogenicity for therapeutic proteins was built by recapitulating key underlying known biological processes for immunogenicity. The model is able to simulate immune responses based on protein-specific antigenic properties (e.g., number of T-epitopes...

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Detalles Bibliográficos
Autores principales: Chen, X, Hickling, T P, Vicini, P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211264/
https://www.ncbi.nlm.nih.gov/pubmed/25184734
http://dx.doi.org/10.1038/psp.2014.31

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211264/
https://www.ncbi.nlm.nih.gov/pubmed/25184734
http://dx.doi.org/10.1038/psp.2014.31

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