A Mechanistic, Multiscale Mathematical Model of Immunogenicity for Therapeutic Proteins: Part 1—Theoretical Model

A mechanistic, multiscale mathematical model of immunogenicity for therapeutic proteins was formulated by recapitulating key biological mechanisms, including antigen presentation, activation, proliferation, and differentiation of immune cells, secretion of antidrug antibodies (ADA), as well as in vi...

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Detalles Bibliográficos
Autores principales: Chen, X, Hickling, T P, Vicini, P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211265/
https://www.ncbi.nlm.nih.gov/pubmed/25184733
http://dx.doi.org/10.1038/psp.2014.30

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211265/
https://www.ncbi.nlm.nih.gov/pubmed/25184733
http://dx.doi.org/10.1038/psp.2014.30

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