Structure-Based Design of Potent and Selective LeishmaniaN-Myristoyltransferase Inhibitors

[Image: see text] Inhibitors of LeishmaniaN-myristoyltransferase (NMT), a potential target for the treatment of leishmaniasis, obtained from a high-throughput screen, were resynthesized to validate activity. Crystal structures bound to Leishmania major NMT were obtained, and the active diastereoisom...

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Detalles Bibliográficos
Autores principales: Hutton, Jennie A., Goncalves, Victor, Brannigan, James A., Paape, Daniel, Wright, Megan H., Waugh, Thomas M., Roberts, Shirley M., Bell, Andrew S., Wilkinson, Anthony J., Smith, Deborah F., Leatherbarrow, Robin J., Tate, Edward W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211304/
https://www.ncbi.nlm.nih.gov/pubmed/25238611
http://dx.doi.org/10.1021/jm5011397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211304/
https://www.ncbi.nlm.nih.gov/pubmed/25238611
http://dx.doi.org/10.1021/jm5011397

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