Polyglutamine Amyloid Core Boundaries and Flanking Domain Dynamics in Huntingtin Fragment Fibrils Determined by Solid-State Nuclear Magnetic Resonance

[Image: see text] In Huntington’s disease, expansion of a polyglutamine (polyQ) domain in the huntingtin (htt) protein leads to misfolding and aggregation. There is much interest in the molecular features that distinguish monomeric, oligomeric, and fibrillar species that populate the aggregation pat...

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Detalles Bibliográficos
Autores principales: Hoop, Cody L., Lin, Hsiang-Kai, Kar, Karunakar, Hou, Zhipeng, Poirier, Michelle A., Wetzel, Ronald, van der Wel, Patrick C. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211650/
https://www.ncbi.nlm.nih.gov/pubmed/25280367
http://dx.doi.org/10.1021/bi501010q

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211650/
https://www.ncbi.nlm.nih.gov/pubmed/25280367
http://dx.doi.org/10.1021/bi501010q

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