Covalent Small Molecule Inhibitors of Ca(2+)-Bound S100B

[Image: see text] Elevated levels of the tumor marker S100B are observed in malignant melanoma, and this EF-hand-containing protein was shown to directly bind wild-type (wt) p53 in a Ca(2+)-dependent manner, dissociate the p53 tetramer, and inhibit its tumor suppression functions. Likewise, inhibiti...

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Detalles Bibliográficos
Autores principales: Cavalier, Michael C., Pierce, Adam D., Wilder, Paul T., Alasady, Milad J., Hartman, Kira G., Neau, David B., Foley, Timothy L., Jadhav, Ajit, Maloney, David J., Simeonov, Anton, Toth, Eric A., Weber, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211652/
https://www.ncbi.nlm.nih.gov/pubmed/25268459
http://dx.doi.org/10.1021/bi5005552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211652/
https://www.ncbi.nlm.nih.gov/pubmed/25268459
http://dx.doi.org/10.1021/bi5005552

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