Independent Relationship between Amyloid Precursor Protein (APP) Dimerization and γ-Secretase Processivity

Altered production of β-amyloid (Aβ) from the amyloid precursor protein (APP) is closely associated with Alzheimer’s disease (AD). APP has a number of homo- and hetero-dimerizing domains, and studies have suggested that dimerization of β-secretase derived APP carboxyl terminal fragment (CTFβ, C99) i...

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Detalles Bibliográficos
Autores principales: Jung, Joo In, Premraj, Sasha, Cruz, Pedro E., Ladd, Thomas B., Kwak, Yewon, Koo, Edward H., Felsenstein, Kevin M., Golde, Todd E., Ran, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211736/
https://www.ncbi.nlm.nih.gov/pubmed/25350374
http://dx.doi.org/10.1371/journal.pone.0111553

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211736/
https://www.ncbi.nlm.nih.gov/pubmed/25350374
http://dx.doi.org/10.1371/journal.pone.0111553

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