Temporal and Anatomical Host Resistance to Chronic Salmonella Infection Is Quantitatively Dictated by Nramp1 and Influenced by Host Genetic Background

The lysosomal membrane transporter, Nramp1, plays a key role in innate immunity and resistance to infection with intracellular pathogens such as non-typhoidal Salmonella (NTS). NTS-susceptible C57BL/6 (B6) mice, which express the mutant Nramp1(D169) allele, are unable to control acute infection with...

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Detalles Bibliográficos
Autores principales: Loomis, Wendy P., Johnson, Matthew L., Brasfield, Alicia, Blanc, Marie-Pierre, Yi, Jaehun, Miller, Samuel I., Cookson, Brad T., Hajjar, Adeline M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211889/
https://www.ncbi.nlm.nih.gov/pubmed/25350459
http://dx.doi.org/10.1371/journal.pone.0111763

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211889/
https://www.ncbi.nlm.nih.gov/pubmed/25350459
http://dx.doi.org/10.1371/journal.pone.0111763

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