Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity

The cyclic nucleotide phosphodiesterase10A (PDE10) has been mostly studied as a therapeutic target for certain psychiatric and neurological conditions, although a potential role in tumorigenesis has not been reported. Here we show that PDE10 is elevated in human colon tumor cell lines compared with...

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Detalles Bibliográficos
Autores principales: Li, Nan, Lee, Kevin, Xi, Yaguang, Zhu, Bing, Gary, Bernard D., Ramírez-Alcántara, Verónica, Gurpinar, Evrim, Canzoneri, Joshua C., Fajardo, Alexandra, Sigler, Sara, Piazza, John T., Chen, Xi, Andrews, Joel, Thomas, Meagan, Lu, Wenyan, Li, Yonghe, Laan, Danuel J., Moyer, Mary P., Russo, Suzanne, Eberhardt, Brian T., Yet, Larry, Keeton, Adam B., Grizzle, William E., Piazza, Gary A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212019/
https://www.ncbi.nlm.nih.gov/pubmed/24704829
http://dx.doi.org/10.1038/onc.2014.94

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212019/
https://www.ncbi.nlm.nih.gov/pubmed/24704829
http://dx.doi.org/10.1038/onc.2014.94

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