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Claudin-4 controls the receptor tyrosine kinase EphA2 pro-oncogenic switch through β-catenin
BACKGROUND: The EphA2 receptor, which is expressed in many types of cancer, is activated by two different mechanisms. Activation by engagement with one of its ephrin ligands is anti-oncogenic whereas phosphorylation of S897 by AKT increases migration, invasion and metastasis. Down-regulation of clau...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212103/ https://www.ncbi.nlm.nih.gov/pubmed/25344320 http://dx.doi.org/10.1186/s12964-014-0059-5 |