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Proteolytic Processing and Activation of Clostridium perfringens Epsilon Toxin by Caprine Small Intestinal Contents

Epsilon toxin (ETX), a pore-forming toxin produced by type B and D strains of Clostridium perfringens, mediates severe enterotoxemia in livestock and possibly plays a role in human disease. During enterotoxemia, the nearly inactive ETX prototoxin is produced in the intestines but then must be activa...

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Detalles Bibliográficos
Autores principales: Freedman, John C., Li, Jihong, Uzal, Francisco A., McClane, Bruce A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212841/
https://www.ncbi.nlm.nih.gov/pubmed/25336460
http://dx.doi.org/10.1128/mBio.01994-14