Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase

Children with Neurofibromatosis type 1 (NF1) are increasingly recognized to have high prevalence of social difficulties and autism spectrum disorders (ASD). We demonstrated selective social learning deficit in mice with deletion of a single Nf1 gene (Nf1(+/−)), along with greater activation of mitog...

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Detalles Bibliográficos
Autores principales: Molosh, Andrei I., Johnson, Philip L., Spence, John P., Arendt, David, Federici, Lauren M., Bernabe, Cristian, Janasik, Steven P., Segu, Zaneer M., Khanna, Rajesh, Goswami, Chirayu, Zhu, Weiguo, Park, Su-Jung, Li, Lang, Mechref, Yehia S., Clapp, D. Wade, Shekhar, Anantha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213300/
https://www.ncbi.nlm.nih.gov/pubmed/25242307
http://dx.doi.org/10.1038/nn.3822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213300/
https://www.ncbi.nlm.nih.gov/pubmed/25242307
http://dx.doi.org/10.1038/nn.3822

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