Cargando…

Real-time observation of signal recognition particle binding to actively translating ribosomes

The signal recognition particle (SRP) directs translating ribosome-nascent chain complexes (RNCs) that display a signal sequence to protein translocation channels in target membranes. All previous work on the initial step of the targeting reaction, when SRP binds to RNCs, used stalled and non-transl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Noriega, Thomas R, Chen, Jin, Walter, Peter, Puglisi, Joseph D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2014
Materias:	Biophysics and Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213662/ https://www.ncbi.nlm.nih.gov/pubmed/25358118 http://dx.doi.org/10.7554/eLife.04418

Ejemplares similares

Folding behavior of a T-shaped, ribosome-binding translation enhancer implicated in a wide-spread conformational switch
por: Le, My-Tra, et al.
Publicado: (2017)

Mapping translation 'hot-spots' in live cells by tracking single molecules of mRNA and ribosomes
por: Katz, Zachary B, et al.
Publicado: (2016)

Ribosome structures to near-atomic resolution from thirty thousand cryo-EM particles
por: Bai, Xiao-chen, et al.
Publicado: (2013)

Structures of translationally inactive mammalian ribosomes
por: Brown, Alan, et al.
Publicado: (2018)

Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition
por: Llácer, Jose Luis, et al.
Publicado: (2018)

A label-free approach to detect ligand binding to cell surface proteins in real time
por: Burtscher, Verena, et al.
Publicado: (2018)

Molecular architecture of the 90S small subunit pre-ribosome
por: Sun, Qi, et al.
Publicado: (2017)

Mechanisms of ribosome stalling by SecM at multiple elongation steps
por: Zhang, Jun, et al.
Publicado: (2015)

Correction: Molecular architecture of the 90S small subunit pre-ribosome
por: Sun, Qi, et al.
Publicado: (2017)

AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter
por: Schulze-Gahmen, Ursula, et al.
Publicado: (2014)

Ribosome•RelA structures reveal the mechanism of stringent response activation
por: Loveland, Anna B, et al.
Publicado: (2016)

Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5′ splice site recognition
por: Kondo, Yasushi, et al.
Publicado: (2015)

A riboswitch separated from its ribosome-binding site still regulates translation
por: Schroeder, Griffin M, et al.
Publicado: (2023)

Observation of long-range tertiary interactions during ligand binding by the TPP riboswitch aptamer
por: Duesterberg, Van K, et al.
Publicado: (2015)

The molecular basis for ANE syndrome revealed by the large ribosomal subunit processome interactome
por: McCann, Kathleen L, et al.
Publicado: (2016)

T cells translate individual, quantal activation into collective, analog cytokine responses via time-integrated feedbacks
por: Tkach, Karen E, et al.
Publicado: (2014)

Real-time imaging of Huntingtin aggregates diverting target search and gene transcription
por: Li, Li, et al.
Publicado: (2016)

A structural model of the active ribosome-bound membrane protein insertase YidC
por: Wickles, Stephan, et al.
Publicado: (2014)

Length-dependent flagellar growth of Vibrio alginolyticus revealed by real time fluorescent imaging
por: Chen, Meiting, et al.
Publicado: (2017)

Dissection of specific binding of HIV-1 Gag to the 'packaging signal' in viral RNA
por: Comas-Garcia, Mauricio, et al.
Publicado: (2017)

Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine
por: Wong, Wilson, et al.
Publicado: (2014)

Activation mechanism of ATP-sensitive K(+) channels explored with real-time nucleotide binding
por: Puljung, Michael, et al.
Publicado: (2019)

Signal recognition particle binds to translating ribosomes before emergence of a signal anchor sequence
por: Mercier, Evan, et al.
Publicado: (2017)

Quantitative imaging reveals real-time Pou5f3–Nanog complexes driving dorsoventral mesendoderm patterning in zebrafish
por: Perez-Camps, Mireia, et al.
Publicado: (2016)

Structural basis for germline antibody recognition of HIV-1 immunogens
por: Scharf, Louise, et al.
Publicado: (2016)

Recognition of the small regulatory RNA RydC by the bacterial Hfq protein
por: Dimastrogiovanni, Daniela, et al.
Publicado: (2014)

Structural basis for recognition and remodeling of the TBP:DNA:NC2 complex by Mot1
por: Butryn, Agata, et al.
Publicado: (2015)

Structure of the active form of human origin recognition complex and its ATPase motor module
por: Tocilj, Ante, et al.
Publicado: (2017)

Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins
por: Atherton, Joseph, et al.
Publicado: (2014)

Lys63-linked ubiquitin chain adopts multiple conformational states for specific target recognition
por: Liu, Zhu, et al.
Publicado: (2015)

Structural basis of pathogen recognition by an integrated HMA domain in a plant NLR immune receptor
por: Maqbool, A, et al.
Publicado: (2015)

Cryo-EM single particle analysis with the Volta phase plate
por: Danev, Radostin, et al.
Publicado: (2016)

Asymmetric recognition of HIV-1 Envelope trimer by V1V2 loop-targeting antibodies
por: Wang, Haoqing, et al.
Publicado: (2017)

Beam-induced motion correction for sub-megadalton cryo-EM particles
por: Scheres, Sjors HW
Publicado: (2014)

Dynamical features of the Plasmodium falciparum ribosome during translation
por: Sun, Ming, et al.
Publicado: (2015)

Structural basis of ribosomal peptide macrocyclization in plants
por: Haywood, Joel, et al.
Publicado: (2018)

Structure of the bacterial ribosome at 2 Å resolution
por: Watson, Zoe L, et al.
Publicado: (2020)

Using the Volta phase plate with defocus for cryo-EM single particle analysis
por: Danev, Radostin, et al.
Publicado: (2017)

Side-binding proteins modulate actin filament dynamics
por: Crevenna, Alvaro H, et al.
Publicado: (2015)

Contacts-based prediction of binding affinity in protein–protein complexes
por: Vangone, Anna, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_t8jff2lu731taq9igorfmjfeip