Validation of serum IGF-I as a biomarker to monitor the bioactivity of exogenous growth hormone agonists and antagonists in rabbits

The development of new growth hormone (GH) agonists and growth hormone antagonists (GHAs) requires animal models for pre-clinical testing. Ideally, the effects of treatment are monitored using the same pharmacodynamic marker that is later used in clinical practice. However, intact rodents are of lim...

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Detalles Bibliográficos
Autores principales: Bielohuby, Maximilian, Zarkesh-Esfahani, Sayyed Hamid, Manolopoulou, Jenny, Wirthgen, Elisa, Walpurgis, Katja, Toghiany Khorasgani, Mohaddeseh, Aghili, Zahra Sadat, Wilkinson, Ian Robert, Hoeflich, Andreas, Thevis, Mario, Ross, Richard J., Bidlingmaier, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213730/
https://www.ncbi.nlm.nih.gov/pubmed/25239917
http://dx.doi.org/10.1242/dmm.016519

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213730/
https://www.ncbi.nlm.nih.gov/pubmed/25239917
http://dx.doi.org/10.1242/dmm.016519

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