The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in mice

Liver kinase B1 (LKB1; also known as STK11) is a serine/threonine kinase and tumour suppressor that is mutated in Peutz-Jeghers syndrome (PJS), a premalignant syndrome associated with the development of gastrointestinal polyps. Proglucagon-expressing enteroendocrine cells are involved in the control...

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Detalles Bibliográficos
Autores principales: Zac-Varghese, Sagen, Trapp, Stefan, Richards, Paul, Sayers, Sophie, Sun, Gao, Bloom, Stephen R., Reimann, Frank, Gribble, Fiona M., Rutter, Guy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213731/
https://www.ncbi.nlm.nih.gov/pubmed/25190708
http://dx.doi.org/10.1242/dmm.014720

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213731/
https://www.ncbi.nlm.nih.gov/pubmed/25190708
http://dx.doi.org/10.1242/dmm.014720

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