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Loss of α-catenin elicits a cholestatic response and impairs liver regeneration
The liver is unique in its capacity to regenerate after injury, during which hepatocytes actively divide and establish cell-cell contacts through cell adhesion complexes. Here, we demonstrate that the loss of α-catenin, a well-established adhesion component, dramatically disrupts liver regeneration....
Autores principales: | Herr, Keira Joann, Tsang, Ying-hung Nicole, Ong, Joanne Wei En, Li, Qiushi, Yap, Lai Lai, Yu, Weimiao, Yin, Hao, Bogorad, Roman L., Dahlman, James E., Chan, Yee Gek, Bay, Boon Huat, Singaraja, Roshni, Anderson, Daniel G., Koteliansky, Victor, Viasnoff, Virgile, Thiery, Jean Paul |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213774/ https://www.ncbi.nlm.nih.gov/pubmed/25355493 http://dx.doi.org/10.1038/srep06835 |
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