Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut

Epithelial-to-mesenchymal transition-like (EMT-like) is a critical process allowing initiation of metastases during tumour progression. Here, to investigate its role in intestinal cancer, we combine computational network-based and experimental approaches to create a mouse model with high metastatic...

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Detalles Bibliográficos
Autores principales: Chanrion, Maia, Kuperstein, Inna, Barrière, Cédric, El Marjou, Fatima, Cohen, David, Vignjevic, Danijela, Stimmer, Lev, Paul-Gilloteaux, Perrine, Bièche, Ivan, Tavares, Silvina Dos Reis, Boccia, Giuseppe-Fulvio, Cacheux, Wulfran, Meseure, Didier, Fre, Silvia, Martignetti, Loredana, Legoix-Né, Patricia, Girard, Elodie, Fetler, Luc, Barillot, Emmanuel, Louvard, Daniel, Zinovyev, Andreï, Robine, Sylvie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214431/
https://www.ncbi.nlm.nih.gov/pubmed/25295490
http://dx.doi.org/10.1038/ncomms6005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214431/
https://www.ncbi.nlm.nih.gov/pubmed/25295490
http://dx.doi.org/10.1038/ncomms6005

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