Cargando…
The Route of HIV Escape from Immune Response Targeting Multiple Sites Is Determined by the Cost-Benefit Tradeoff of Escape Mutations
Cytotoxic T lymphocytes (CTL) are a major factor in the control of HIV replication. CTL arise in acute infection, causing escape mutations to spread rapidly through the population of infected cells. As a result, the virus develops partial resistance to the immune response. The factors controlling th...
Autores principales: | Batorsky, Rebecca, Sergeev, Rinat A., Rouzine, Igor M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214571/ https://www.ncbi.nlm.nih.gov/pubmed/25356981 http://dx.doi.org/10.1371/journal.pcbi.1003878 |
Ejemplares similares
-
Estimating Costs and Benefits of CTL Escape Mutations in SIV/HIV Infection
por: Ganusov, Vitaly V, et al.
Publicado: (2006) -
HIV CTL escape: at what cost?
por: Smith, Stephen M
Publicado: (2004) -
Determinants of HIV-1 Mutational Escape From Cytotoxic T Lymphocytes
por: Yang, Otto O., et al.
Publicado: (2003) -
Escape mutations circumvent a tradeoff between resistance to a beta-lactam and resistance to a beta-lactamase inhibitor
por: Russ, Dor, et al.
Publicado: (2020) -
HIV switches to escape
por: Bashyam, Hema
Publicado: (2008)