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TIF-IA-Dependent Regulation of Ribosome Synthesis in Drosophila Muscle Is Required to Maintain Systemic Insulin Signaling and Larval Growth

The conserved TOR kinase signaling network links nutrient availability to cell, tissue and body growth in animals. One important growth-regulatory target of TOR signaling is ribosome biogenesis. Studies in yeast and mammalian cell culture have described how TOR controls rRNA synthesis—a limiting ste...

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Detalles Bibliográficos
Autores principales: Ghosh, Abhishek, Rideout, Elizabeth J., Grewal, Savraj S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214618/
https://www.ncbi.nlm.nih.gov/pubmed/25356674
http://dx.doi.org/10.1371/journal.pgen.1004750