Suppression of Chemotaxis by SSeCKS via Scaffolding of Phosphoinositol Phosphates and the Recruitment of the Cdc42 GEF, Frabin, to the Leading Edge

Chemotaxis is controlled by interactions between receptors, Rho-family GTPases, phosphatidylinositol 3-kinases, and cytoskeleton remodeling proteins. We investigated how the metastasis suppressor, SSeCKS, attenuates chemotaxis. Chemotaxis activity inversely correlated with SSeCKS levels in mouse emb...

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Detalles Bibliográficos
Autores principales: Ko, Hyun-Kyung, Guo, Li-wu, Su, Bing, Gao, Lingqiu, Gelman, Irwin H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214753/
https://www.ncbi.nlm.nih.gov/pubmed/25356636
http://dx.doi.org/10.1371/journal.pone.0111534

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214753/
https://www.ncbi.nlm.nih.gov/pubmed/25356636
http://dx.doi.org/10.1371/journal.pone.0111534

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