Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly

The HIV-1 capsid is involved in all infectious steps from reverse transcription to integration site selection, and is the target of multiple host cell and pharmacologic ligands. However, structural studies have been limited to capsid monomers (CA), and the mechanistic basis for how these ligands inf...

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Detalles Bibliográficos
Autores principales: Price, Amanda J., Jacques, David A., McEwan, William A., Fletcher, Adam J., Essig, Sebastian, Chin, Jason W., Halambage, Upul D., Aiken, Christopher, James, Leo C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214760/
https://www.ncbi.nlm.nih.gov/pubmed/25356722
http://dx.doi.org/10.1371/journal.ppat.1004459

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214760/
https://www.ncbi.nlm.nih.gov/pubmed/25356722
http://dx.doi.org/10.1371/journal.ppat.1004459

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