PRPF8 Defects Cause Missplicing in Myeloid Malignancies

Mutations of spliceosome components are common in myeloid neoplasms. One of the affected genes, PRPF8, encodes the most evolutionarily conserved spliceosomal protein. We identified either recurrent somatic PRPF8 mutations or hemizygous deletions in 15/447 and 24/450 cases, respectively. 50% of PRPF8...

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Detalles Bibliográficos
Autores principales: Kurtovic-Kozaric, Amina, Przychodzen, Bartlomiej, Singh, Jarnail, Konarska, Maria M., Clemente, Michael J., Otrock, Zaher K., Nakashima, Meghan, Hsi, Eric D., Yoshida, Kenichi, Ogawa, Seishi, Boultwood, Jacqueline, Maciejewski, Jaroslaw P., Padgett, Richard A., Makishima, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214909/
https://www.ncbi.nlm.nih.gov/pubmed/24781015
http://dx.doi.org/10.1038/leu.2014.144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214909/
https://www.ncbi.nlm.nih.gov/pubmed/24781015
http://dx.doi.org/10.1038/leu.2014.144

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