Conditional tolerance of temperate phages via transcription-dependent CRISPR-Cas targeting

A fundamental feature of immune systems is the ability to distinguish pathogenic from self and commensal elements, and to attack the former but tolerate the latter(1). Prokaryotic CRISPR-Cas immune systems defend against phage infection using Cas nucleases and small RNA guides that specify one or mo...

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Detalles Bibliográficos
Autores principales: Goldberg, Gregory W., Jiang, Wenyan, Bikard, David, Marraffini, Luciano A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214910/
https://www.ncbi.nlm.nih.gov/pubmed/25174707
http://dx.doi.org/10.1038/nature13637

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214910/
https://www.ncbi.nlm.nih.gov/pubmed/25174707
http://dx.doi.org/10.1038/nature13637

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