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A system for the continuous directed evolution of proteases rapidly reveals drug-resistance mutations
The laboratory evolution of protease enzymes has the potential to generate proteases with therapeutically relevant specificities, and to assess the vulnerability of protease inhibitor drug candidates to the evolution of drug resistance. Here we describe a system for the continuous directed evolution...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215169/ https://www.ncbi.nlm.nih.gov/pubmed/25355134 http://dx.doi.org/10.1038/ncomms6352 |