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NF1 regulation of RAS/ERK signaling is required for appropriate granule neuron progenitor expansion and migration in cerebellar development

Cerebellar development is regulated by a coordinated spatiotemporal interplay between granule neuron progenitors (GNPs), Purkinje neurons, and glia. Abnormal development can trigger motor deficits, and more recent data indicate important roles in aspects of memory, behavior, and autism spectrum diso...

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Detalles Bibliográficos
Autores principales: Sanchez-Ortiz, Efrain, Cho, Woosung, Nazarenko, Inga, Mo, Wei, Chen, Jian, Parada, Luis F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215185/
https://www.ncbi.nlm.nih.gov/pubmed/25367036
http://dx.doi.org/10.1101/gad.246603.114