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Coordination of insulin and Notch pathway activities by microRNA miR-305 mediates adaptive homeostasis in the intestinal stem cells of the Drosophila gut

Homeostasis of the intestine is maintained by dynamic regulation of a pool of intestinal stem cells. The balance between stem cell self-renewal and differentiation is regulated by the Notch and insulin signaling pathways. Dependence on the insulin pathway places the stem cell pool under nutritional...

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Autores principales: Foronda, David, Weng, Ruifen, Verma, Pushpa, Chen, Ya-Wen, Cohen, Stephen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215186/
https://www.ncbi.nlm.nih.gov/pubmed/25367037
http://dx.doi.org/10.1101/gad.241588.114
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author Foronda, David
Weng, Ruifen
Verma, Pushpa
Chen, Ya-Wen
Cohen, Stephen M.
author_facet Foronda, David
Weng, Ruifen
Verma, Pushpa
Chen, Ya-Wen
Cohen, Stephen M.
author_sort Foronda, David
collection PubMed
description Homeostasis of the intestine is maintained by dynamic regulation of a pool of intestinal stem cells. The balance between stem cell self-renewal and differentiation is regulated by the Notch and insulin signaling pathways. Dependence on the insulin pathway places the stem cell pool under nutritional control, allowing gut homeostasis to adapt to environmental conditions. Here we present evidence that miR-305 is required for adaptive homeostasis of the gut. miR-305 regulates the Notch and insulin pathways in the intestinal stem cells. Notably, miR-305 expression in the stem cells is itself under nutritional control via the insulin pathway. This link places regulation of Notch pathway activity under nutritional control. These findings provide a mechanism through which the insulin pathway controls the balance between stem cell self-renewal and differentiation that is required for adaptive homeostasis in the gut in response to changing environmental conditions.
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spelling pubmed-42151862014-11-04 Coordination of insulin and Notch pathway activities by microRNA miR-305 mediates adaptive homeostasis in the intestinal stem cells of the Drosophila gut Foronda, David Weng, Ruifen Verma, Pushpa Chen, Ya-Wen Cohen, Stephen M. Genes Dev Research Paper Homeostasis of the intestine is maintained by dynamic regulation of a pool of intestinal stem cells. The balance between stem cell self-renewal and differentiation is regulated by the Notch and insulin signaling pathways. Dependence on the insulin pathway places the stem cell pool under nutritional control, allowing gut homeostasis to adapt to environmental conditions. Here we present evidence that miR-305 is required for adaptive homeostasis of the gut. miR-305 regulates the Notch and insulin pathways in the intestinal stem cells. Notably, miR-305 expression in the stem cells is itself under nutritional control via the insulin pathway. This link places regulation of Notch pathway activity under nutritional control. These findings provide a mechanism through which the insulin pathway controls the balance between stem cell self-renewal and differentiation that is required for adaptive homeostasis in the gut in response to changing environmental conditions. Cold Spring Harbor Laboratory Press 2014-11-01 /pmc/articles/PMC4215186/ /pubmed/25367037 http://dx.doi.org/10.1101/gad.241588.114 Text en © 2014 Foronda et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by/4.0/ This article, published in Genes & Development, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0.
spellingShingle Research Paper
Foronda, David
Weng, Ruifen
Verma, Pushpa
Chen, Ya-Wen
Cohen, Stephen M.
Coordination of insulin and Notch pathway activities by microRNA miR-305 mediates adaptive homeostasis in the intestinal stem cells of the Drosophila gut
title Coordination of insulin and Notch pathway activities by microRNA miR-305 mediates adaptive homeostasis in the intestinal stem cells of the Drosophila gut
title_full Coordination of insulin and Notch pathway activities by microRNA miR-305 mediates adaptive homeostasis in the intestinal stem cells of the Drosophila gut
title_fullStr Coordination of insulin and Notch pathway activities by microRNA miR-305 mediates adaptive homeostasis in the intestinal stem cells of the Drosophila gut
title_full_unstemmed Coordination of insulin and Notch pathway activities by microRNA miR-305 mediates adaptive homeostasis in the intestinal stem cells of the Drosophila gut
title_short Coordination of insulin and Notch pathway activities by microRNA miR-305 mediates adaptive homeostasis in the intestinal stem cells of the Drosophila gut
title_sort coordination of insulin and notch pathway activities by microrna mir-305 mediates adaptive homeostasis in the intestinal stem cells of the drosophila gut
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215186/
https://www.ncbi.nlm.nih.gov/pubmed/25367037
http://dx.doi.org/10.1101/gad.241588.114
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