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Systematic Comparison of Molecular Conformations of H(+),K(+)-ATPase Reveals an Important Contribution of the A-M2 Linker for the Luminal Gating
Gastric H(+),K(+)-ATPase, an ATP-driven proton pump responsible for gastric acidification, is a molecular target for anti-ulcer drugs. Here we show its cryo-electron microscopy (EM) structure in an E2P analog state, bound to magnesium fluoride (MgF), and its K(+)-competitive antagonist SCH28080, det...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215238/ https://www.ncbi.nlm.nih.gov/pubmed/25231997 http://dx.doi.org/10.1074/jbc.M114.584623 |